In 1973, he was appointed Assistant Professor at the University of Pittsburgh, where he taught courses in Statistics and Statistical Decision Theory. In 1977, Dr. Mehta left the University of Pittsburgh and joined Harvard School of Public Health as Post Doctoral Fellow in Biostatistics and worked at Dana-Farber Cancer Institute, Boston. In 1979, he joined the faculty at Harvard TC Chan School of Public Health as an Assistant and then Associate Professor of Biostatistics. He also served as a clinical trials Statistician for major oncology trials sponsored by the US National Cancer Institute.
With Operations Research as the background, Dr. Mehta together with his MIT Colleague Mr. Nitin Patel, developed fast numerical algorithms for accurate test of efficacy and safety of cancer drugs. He founded Cytel Inc, in 1987, which was a spin-off from this Harvard research with a mission to develop software and services for clinical drug development. Over the years Cytel has developed industry standard statistical software for designing and monitoring clinical trials in flexible ways so as to assign more patients to better treatments and get new drugs to market faster. Starting from a four-person operation in Dr. Mehta’s home in Cambridge, Massachusetts, Cytel has grown into a 600-person company with offices in USA, Europe and India.
Dr. Mehta has won several awards. A few of which are: George W. Snedecor award for the best paper in Biometry – Joint award from the American Statistical Association in 1989; Elected Fellow of the American Statistical Association in 1995; Massachusetts Technology Collaborative Small Business Award – Awarded to Cytel in 1999; Fredrick Mosteller Statistician of the Year by the Boston Chapter of the American Statistical Association in 2000; Entrepreneur of the Year by the World Zoroastrian Chamber of Commerce in 2003; and Lifetime Achievement Award by the International Indian Statistical Association in 2015.